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  • Title: Effect of omeprazole on serum gastrin levels: influence of age and sex.
    Author: Koop H, Naumann-Koch C, Arnold R.
    Journal: Z Gastroenterol; 1990 Nov; 28(11):603-5. PubMed ID: 1981116.
    Abstract:
    Serum gastrin levels were determined in 120 consecutive patients (43 females, 77 males) with peptic disease 24 h post dose after 4 weeks continuous omeprazole (40 mg daily) treatment. Serum gastrin levels were elevated in 33 (28%) but exceeded the twice normal range in only 6 patients (5%). Age and sex did not influence the magnitude of gastrin levels. Gastrin increments induced by omeprazole compared to pretreatment with H2-blockers in 60 cases were similar in both males (42 +/- 10 pg/ml) and females (44 +/- 9 pg/ml). It is concluded that the magnitude of gastrin increases observed during omeprazole therapy are small and independent of age and sex.
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