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  • Title: Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor gamma delta-CD3.
    Author: Shimada S, Caughman SW, Bluestone JA, Cron RQ, Owen FL, Smith JA, Katz SI.
    Journal: J Dermatol Sci; 1990 Nov; 1(6):459-64. PubMed ID: 1981147.
    Abstract:
    Within murine epidermis exists a population of Thy-1+ DEC which express membrane Thy-1 antigen, but lack CD8 or CD4 antigen. We examined freshly obtained non-cultured Thy-1+ DEC both by immunofluorescence and by biochemical techniques to identify the protein products of the T cell receptor (TCR) and the associated CD3 complex on these cells. Virtually all of the Thy-1+ DEC are brightly positive in CD3 expression with immunofluorescence using the monoclonal antibody 145-2C11. By immunoprecipitation, using this same antibody and polyclonal anti-TCR-gamma antibody, the only TCR heterodimer detected on the freshly isolated Thy-1+ DEC is the gamma delta heterodimer. These findings suggest that in the phenotype and TCR expression, Thy-1+ DEC are analogous to CD8-, CD4- early fetal thymocytes.
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