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  • Title: [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation].
    Author: Huang ZY, Liu QP, Li WZ, Wang RJ, Chi Y, Liu YY, Zhang QM.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2009 Oct; 25(10):879-82. PubMed ID: 19811731.
    Abstract:
    AIM: Investigated the relationship between NF-kappaB activation and cell apoptosis in mouse macrophages treated with 7-ketochesterol (7-KC). METHODS: Cell apoptosis was detected by MTT assay, DNA fragmentation assay and flow cytometric analysis. NF-kappaB activation was detected by western blot and immunohistochemistry. Inhibitory assay was used to show the effect of the activation of NF-kappaB on the apoptosis induced by 7-KC. RESULTS: 7-KC inhibited macrophages proliferation, and then induced apoptosis, which is associated with NF-kappaB activation. Moreover, cell apoptosis with NF-kappaB activation was inhibited by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB. CONCLUSION: 7-KC induced the activation of NF-kappaB and following cell apoptosis.
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