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  • Title: Prostaglandin E1 modifies nerve conduction and interferes with local anaesthetic action.
    Author: Horrobin DF, Durand LG, Manku MS.
    Journal: Prostaglandins; 1977 Jul; 14(1):103-8. PubMed ID: 19812.
    Abstract:
    Prostaglandin E1 (PGE1) altered both the amplitude and conduction velocity of the compound action potential in frog sciatic nerve. Concentrations up to 1 ng/ml increased both amplitude and conduction velocity but at higher concentrations both effects were reversed. Procaine, chloroquine, indomethacin and SC19220 all reduced action potential amplitude and conduction velocity. These local anaesthetic type actions could be partially or completely prevented by PGE1.
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