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  • Title: Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation.
    Author: Katoh N, Matsuda M, Yoshida T, Yazaki M, Morita H, Sakashita K, Ikeda S.
    Journal: Muscle Nerve; 2010 Jan; 41(1):138-43. PubMed ID: 19813189.
    Abstract:
    We report 2 patients with polyneuropathy associated with amyloid derived from light chains (AL) who were treated successfully with high-dose melphalan followed by autologous peripheral blood stem cell transplantation (HDM/SCT). Neuropathic symptoms improved in conjunction with normalization of serum-free light chains. In addition to amyloid deposits in tissues, an amyloidogenic light chain itself produced by abnormal plasma cells might be harmful to peripheral nerve function, and thus HDM/SCT seems to be a promising therapy for primary AL amyloid polyneuropathy.
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