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  • Title: Biphenyls from Berberis koreana.
    Author: Kim KH, Choi SU, Ha SK, Kim SY, Lee KR.
    Journal: J Nat Prod; 2009 Nov; 72(11):2061-4. PubMed ID: 19813743.
    Abstract:
    Three new biphenyls, berbekorin A (1), 2'-hydroxy-3,4,5-trimethoxybiphenyl (2), and 4,5-dihydroxy-3-methoxybiphenyl (3), together with 11 known biphenyls (4-14), were isolated from the n-hexane-soluble fraction of the MeOH extract of the trunk of Berberis koreana. The structures of 1-3 were determined by spectroscopic methods, including 1D and 2D NMR analysis. Compound 1 exhibited cytotoxic activity against the SK-MEL-2 skin melanoma cell line, in particular. Moreover, compounds 2, 5, 6, and 14 inhibited NO production in LPS-activated BV-2 cells, a microglial cell line.
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