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  • Title: Synthesis and antimicrobial studies of s-triazine based heterocycles.
    Author: Patel DH, Chikhalia KH, Shah NK, Patel DP, Kaswala PB, Buha VM.
    Journal: J Enzyme Inhib Med Chem; 2010 Feb; 25(1):121-5. PubMed ID: 19814592.
    Abstract:
    In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evalution of various series of 2-(N-methylamino)-4-(N,N-dimethylamino)-6-(arylthioureido)-s-triazine (5a-j) and (N-methylamino)-4-(N,N-dimethylamino)-6-(arylureido)-s-triazine (6a-j). All the synthesized compounds were screened in vitro for their antibacterial activity against two different gram-positive bacteria (S. aureus, B. subtilis) and two different gram-negative bacteria (P. aeruginosa, E. coli) using the broth dilution method.
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