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  • Title: Frusemide potentiates acetylcholine and carbachol in contracting the rat urinary bladder.
    Author: Okpukpara JN, Akah PA.
    Journal: J Pharm Pharmacol; 1990 Aug; 42(8):597-8. PubMed ID: 1981595.
    Abstract:
    The interaction between acetylcholine and carbachol, and frusemide, a loop diuretic, have been studied on the rat isolated urinary bladder strip preparation. Acetylcholine (4.36 x 10(-8) - 1.3 x 10(-6) M) and carbachol (5.5 x 10(-8) - 6.9 x 10(-6) M) induced contractions and these were significantly potentiated by frusemide (3.02 x 10(-6) M). The ratio of EC50 in the absence of frusemide to EC50 in the presence of frusemide was 1.58 +/- 0.03 (s.e.m.) for acetylcholine and 1.86 +/- 0.14 for carbachol. Potentiation of acetylcholine and carbachol contractions by frusemide was not observed in tissues treated with hexamethonium (2.5 x 10(-5) M). Rhythmic contractions induced by frusemide alone were markedly reduced by hexamethonium (2.5 x 10(-5) M) and tetrodotoxin (10(-6) M) but they were not significantly reduced by atropine (1.7 x 10(-6) M). The result suggests that frusemide increases the sensitivity of the bladder to acetylcholine and carbachol, and that it may have a nicotinic stimulant effect on the bladder. This extra-renal action may contribute to its prompt diuretic property.
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