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  • Title: [Comparative activity of endorphins on the opiate receptors].
    Author: Vallée E, Chambon JP, Delahayes J.
    Journal: C R Acad Hebd Seances Acad Sci D; 1977 Jul 18; 285(3):257-60. PubMed ID: 198160.
    Abstract:
    Displacement of naloxone from membranes of Rat brain by alpha, beta and gamma-endorphins with and without Na+ in the incubating medium has been studied. beta-endorphin shows a higher affinity for the opiate receptors and a stronger agonist property than morphine. alpha and gamma-endorphins have a much lower affinity than morphine and a marked antagonist characteristic. This study suggests the possibility of naturally occurring antagonists of the opiate receptors.
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