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  • Title: Adalimumab treatment for life threatening pulmonary artery aneurysm in Behçet disease: a case report.
    Author: Lee SW, Lee SY, Kim KN, Jung JK, Chung WT.
    Journal: Clin Rheumatol; 2010 Jan; 29(1):91-3. PubMed ID: 19816754.
    Abstract:
    Behçet's disease (BD) is a multisystem disorder characterized by vasculitis. Pulmonary vascular problems such as pulmonary artery aneurysms (PAA) are reported to indicate poor prognosis and high mortality. We describe a 43-year-old man who presented with life threatening bilateral PAA and thromboembolic disease due to BD. He was treated with prednisone and pulse cyclophosphamide and was poorly responsive to the conventional immunosuppression. The introduction of adalimumab therapy stabilized his PAA. We report that the inhibition of TNF-alpha using the neutralizing monoclonal antibody adalimumab has the potential to induce rapid, complete, and long-lasting remission in a life-threatening manifestation of BD.
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