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  • Title: Synthesis and biological activity of dialkylphosphocholines.
    Author: Lukác M, Mrva M, Fischer-Fodor E, Lacko I, Bukovský M, Miklásová N, Ondriska F, Devínsky F.
    Journal: Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6346-9. PubMed ID: 19818608.
    Abstract:
    A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells.
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