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  • Title: Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species.
    Author: Rojas-Rivera D, Díaz-Elizondo J, Parra V, Salas D, Contreras A, Toro B, Chiong M, Olea-Azar C, Lavandero S.
    Journal: FEBS Lett; 2009 Nov 03; 583(21):3485-92. PubMed ID: 19818777.
    Abstract:
    We investigated the role of Ca(2+) in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic and mitochondrial Ca(2+). Nifedipine (Nife) inhibited both Hypo-induced Ca(2+) and ROS increases. Overexpression of catalase (CAT) induced RVD and a decrease in Hypo-induced blebs. Nife prevented CAT-dependent RVD activation. These results show a dual role of Hypo-induced Ca(2+) influx in the control of cardiomyocyte viability. Hypo-induced an intracellular Ca(2+) increase which activated RVD and inhibited necrotic blebbing thus favoring cell survival, while simultaneously increasing ROS generation, which in turn inhibited RVD and induced necrosis.
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