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  • Title: [The analgesic action of narcotic analgesics and clopheline after the ionizing irradiation of rats].
    Author: Ignatov IuD, Zaĭtsev AA, Abdrakhmanov AA.
    Journal: Farmakol Toksikol; 1990; 53(6):17-9. PubMed ID: 1981987.
    Abstract:
    The ionizing radiation (150 Gy) extended the rat tail flick latency, decreased the pain-relief effects of morphine and opioids and enhanced the analgesic effect of clopheline. The radiation was followed by a decrease of vocalization threshold with a reduction of morphine- and clopheline-induced analgesia. Naloxone (0.1 mg/kg) eliminated the postradiation analgesia and did not change the hyperalgesic effect of the radiation.
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