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  • Title: New method for isolation of venom from the sea anemone Actinia cari. Purification and characterization of cytolytic toxins.
    Author: Sencic L, Macek P.
    Journal: Comp Biochem Physiol B; 1990; 97(4):687-93. PubMed ID: 1982253.
    Abstract:
    1. Venom from the sea anemone Actinia cari was obtained by the "milking" method. Two lethal and hemolytic polypeptide toxins, caritoxins I (CTX I) and II (CTX II), were isolated with gel and ion exchange chromatography. 2. The mol. wt of the pure toxin was 19,800. The isoelectric points of CTX I and II were 9.45 and 10.0, respectively. The toxins had similar amino acid compositions lacking cysteine. 3. The intravenous CTX I and CTX II lethal dose (LD50) in mice was found to be 54 +/- 25 and 90 +/- 1 micrograms/kg, respectively. Their hemolytic activity was inhibited by sphingomyelin.
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