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  • Title: Chloral hydrate anesthesia antagonizes the neurotoxicity of 3,4-methylenedioxymethamphetamine.
    Author: Schmidt CJ, Black CK, Abbate GM, Taylor VL.
    Journal: Eur J Pharmacol; 1990 Nov 27; 191(2):213-6. PubMed ID: 1982264.
    Abstract:
    We report that maintaining rats under chloral hydrate anesthesia for the first 3 h following the administration of 3,4-methylenedioxymethamphetamine (MDMA) blocks the decrease in forebrain concentrations of 5-hydroxytryptamine (5-HT) measured 1 week later. In contrast, the acute effect of MDMA (3 h) on forebrain 5-HT was not altered by the anesthetic. This protective effect of chloral hydrate was not due to an anesthetic-induced hypothermia but may be related to the hypothesized role of dopamine in the neurotoxic effects of MDMA.
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