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  • Title: Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta).
    Author: Grimaldi G, Porrozzi R, Friedrich K, Teva A, Marchevsky RS, Vieira F, Miekeley N, Paumgartten FJ.
    Journal: Antimicrob Agents Chemother; 2010 Jan; 54(1):502-5. PubMed ID: 19822700.
    Abstract:
    This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.
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