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  • Title: Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats.
    Author: Poland RE.
    Journal: Neuropharmacology; 1990 Nov; 29(11):1099-101. PubMed ID: 1982341.
    Abstract:
    Although (+/-) methylenedioxymethamphetamine (MDMA) has been reported to deplete serotonin (5-HT) and destroy 5-HT terminals in the brains of animals, the functional sequelae of such alterations remain to be established. In the present study, a blunted corticotropin and an enhanced prolactin response to the 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH DPAT) was found in rats treated two weeks previously with a single dose of MDMA (2.0 or 20.0 mg/kg, sc). These results suggest that neurochemical changes produced by MDMA are associated with functional alterations as manifested by abnormal 5-HT receptor-coupled neuroendocrine responses.
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