These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regulation of TRH release by the cultured neonate rat pancreas.
    Author: Dutour A, Giraud P, Maltese JY, Becquet D, Pesce G, Salers P, Ouafik LH, Renard M, Oliver C.
    Journal: Peptides; 1990; 11(6):1081-5. PubMed ID: 1982349.
    Abstract:
    The TRH secretory responsiveness of the pancreatic islet cell clusters from newborn rat in organ culture was studied. Basal TRH secretion was stable over a 9-day period. The response to various secretagogues was tested on day 4. TRH secretion was stimulated by high potassium-induced depolarization and also through both cAMP and protein kinase-C dependent pathways. Like insulin, TRH release was stimulated by glucose and arginine and inhibited by somatostatin. These data suggest the existence of a common mechanism for TRH and insulin secretion by the pancreatic beta-cells.
    [Abstract] [Full Text] [Related] [New Search]