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  • Title: Risk-adapted treatment of pediatric acute lymphoblastic leukemia.
    Author: Jeha S, Pui CH.
    Journal: Hematol Oncol Clin North Am; 2009 Oct; 23(5):973-90, v. PubMed ID: 19825448.
    Abstract:
    Optimal use of antileukemic agents and stringent application of risk-directed therapy in clinical trials have resulted in steady improvement in the outcome of children with acute lymphoblastic leukemia, with current cure rates exceeding 80% in developed countries. The intensity of treatment varies substantially among subsets of patients, as therapy is designed to reduce acute and long-term toxicity in low-risk groups while improving outcomes in poor risk groups by treatment intensification. Recent advances in genome-wide screening techniques, pharmacogenomic studies, and development of molecular therapeutics are ushering in an era of more refined personalized therapy.
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