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  • Title: Chronic actions of thyroxine on behavior and serotonin receptors in mouse strains with contrasting predispositions to catalepsy.
    Author: Zubkov EA, Kulikov AV, Naumenko VS, Popova NK.
    Journal: Neurosci Behav Physiol; 2009 Nov; 39(9):909-14. PubMed ID: 19826957.
    Abstract:
    The studies reported here addressed the effects of chronic administration of thyroxine (2 mg/liter for 60 days) on catalepsy and the functional activity and expression of the 5-HT(1A) and 5-HT(2A) receptor genes in the brains of adult male mice of the cataleptic ASC strain and the catalepsy-resistant AKR strain. Thyroxine induced cataleptics in AKR mice but had anticataleptic activity in ASC animals. Chronic thyroxine administration increased the functional activity and expression of 5-HT(2A) receptors in the frontal cortex in AKR mice but not in ASC mice. In ASC mice, the hormone significantly weakened the hypothermic effect of the 5-HT(1A) receptor agonist 8-OH-DPAT, though it did not alter the expression of these receptors. These results suggest that 5-HT(2A) receptors are involved in the cataleptogenic while 5-HT(1A) receptors are involved in the anticataleptic effects of the hormone in mice.
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