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  • Title: [Three cases of isocyanate-induced hypersensitivity pneumonitis with different HRCT findings].
    Author: Hara S, Yamamoto K, Yoda A, Nakayama S, Sakamoto N, Ishimatsu Y, Mukae H, Kohno S.
    Journal: Nihon Kokyuki Gakkai Zasshi; 2009 Sep; 47(9):839-43. PubMed ID: 19827591.
    Abstract:
    We reported 3 cases of hypersensitivity pneumonitis who had been exposed to polyurethane material containing diphenylmethane diisocyanate (MDI) for 1-12 weeks. They had cough, fever and dyspnea before admission. All 3 cases were diagnosed immunologically using anti-MDI antibodies. Chest HRCT findings of the 3 cases were different. Case 1 showed an organizing pneumonia (OP) pattern : patchy peripheral consolidation with air bronchogram and ground-glass opacities (GGO), and case 2 showed a nonspecific interstitial pneumonia (NSIP) pattern : consolidation and reticular shadows in both lower lobes. In addition, case 3 showed a hypersensitivity pneumonitis (HP) pattern : centrilobular GGO and diffuse granular shadows. All cases were successfully treated by corticosteroids alone. This suggests that different amounts of inhaled antigen can cause different HRCT findings.
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