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  • Title: Tubulosine: an antitumor constituent of Pogonopus speciosus.
    Author: Ma WW, Anderson JE, McKenzie AT, Byrn SR, McLaughlin JL, Hudson MS.
    Journal: J Nat Prod; 1990; 53(4):1009-14. PubMed ID: 1982768.
    Abstract:
    From the antitumor-bioactive sap of Pogonopus speciosus, tubulosine [1] was isolated, by activity-directed fractionation using the brine shrimp lethality test, as the major antitumor constituent. 1H-nmr assignments, obtained from HETCOR and COSY, and X-ray crystallographic results are reported for the first time. Psychotrine [2] was also isolated, and its spectral data are also reported.
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