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  • Title: [Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?].
    Author: Herman WA, Seńko A, Korczowska I, Łacka K.
    Journal: Pol Merkur Lekarski; 2009 Sep; 27(159):197-201. PubMed ID: 19827728.
    Abstract:
    UNLABELLED: The occurrence of metabolic syndrome (MS) and osteoporosis is essentials danger for public health. It seems that one of epidemiological factors of those diseases is age-depending adrenal androgens deficiency. AIM OF THE STUDY: was to evaluate relationships between DHEA/DHEAS serum levels and BMD along with frequency of MS in ageing Caucasian men. MATERIALS AND METHODS: In 271 randomly chosen men aged 40 to 80 years living in Lubuskie district (Poland) adrenal androgens, anthropometrical indices in addition to densitometry were estimated. RESULTS: DHEA/DHEAS serum levels showed positive correlation with BMD (r = 0.16 and r = 0.18, respectively, p < 0.001). Statistic essential dependencies between decreased adrenal androgens and coexistence of neoplastic diseases (p < 0.001), hypertension (p < 0.05), peripheral perfusion disturbances (p < 0.005) and dementia (p < 0.0001) were also observed. CONCLUSIONS: The evaluation of DHEA/DHEAS serum level is useful in estimation of general health status of ageing men, but does not identify participants suffering from metabolic syndrome.
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