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  • Title: Asymmetric hydrogenation of enamides, alpha-enol and alpha-enamido ester phosphonates catalyzed by IndolPhos-Rh complexes.
    Author: Wassenaar J, Reek JN.
    Journal: J Org Chem; 2009 Nov 06; 74(21):8403-6. PubMed ID: 19827781.
    Abstract:
    The scope of the IndolPhos-Rh-catalyzed asymmetric hydrogenation of enamides, alpha-enol and alpha-enamido ester phosphonates, has been investigated. In addition, Taddol-based IndolPhos ligands are introduced. High activities and good to excellent enantioselectivities up to 99% ee are obtained for a broad range of structurally diverse substrates, giving important chiral products such as alpha, beta(2), and beta(3) amino acid derivatives, arylamines, and amino and hydroxy phosphonates.
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