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  • Title: [Langerhans cell histiocytosis].
    Author: Ben Slama L, Ruhin B, Zoghbani A.
    Journal: Rev Stomatol Chir Maxillofac; 2009 Nov; 110(5):287-9. PubMed ID: 19828161.
    Abstract:
    Langerhans cell histiocytosis (ex histiocytosis X) is usually present in children. It is a clonal proliferation of non-functional Langerhans's cells. Histological aspects are variable. The diagnosis is made in immunolabeling by anti-CD1a. Clinical presentations are variable, depending on their extension. Three syndromes are actually the same pathogenic process: eosinophilic granuloma (single or multiple osseous localizations), Hand-Schüller-Christian disease (chronic form with bone and visceral dissemination) and Abt-Letterer-Siwe disease (disseminated and acute malignant presentation).
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