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  • Title: The effects of osteoformin on mineralisation and quality of newly formed bone during mandibular distraction osteogenesis in rabbits.
    Author: Pampu AA, Ozkaynak O, Senel FC, Cankaya M, Dolanmaz D, Ersöz S, Avunduk MC.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Dec; 108(6):833-7. PubMed ID: 19828342.
    Abstract:
    OBJECTIVE: The aim of this experimental study was to evaluate the effects of osteoformin on mineralization and quality of newly formed bone during distraction osteogenesis in rabbits. STUDY DESIGN: Distraction rate was as 1 mm/day for 5 days. In the experimental group, 100 microg/kg osteoformin in 100 microL/kg phosphate-buffered saline (PBS) was injected into the distraction area at day 1 and day 7 after surgery. In the control group, only 100 microL/kg PBS was injected on the same days. On day 42, the animals were killed. RESULTS: Bone mineral density and bone mineral content values increased significantly in the experimental group (P < .05). Newly formed bone areas, number of vessels and osteoblasts were significantly greater in experimental group (P < .05). The number of fibroblasts were also greater, but it was not significant statistically (P > .05). The number of osteoclasts was significantly lower in experimental group (P < .05). CONCLUSION: The results of this study show that osteoformin improves healing of regenerate in distraction osteogenesis in rabbits.
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