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  • Title: Hepatic steatosis is uncommon in children with chronic hepatitis B.
    Author: Giannattasio A, Cirillo F, Terlizzi V, Liccardo D, Vecchione R, Iorio R.
    Journal: J Clin Virol; 2009 Dec; 46(4):360-2. PubMed ID: 19828370.
    Abstract:
    BACKGROUND: Differently from chronic hepatitis C, factors associated with hepatic steatosis in children with chronic hepatitis B are not clearly elucidated. OBJECTIVE: Aim of this study was to investigate prevalence of steatosis at liver biopsy in HBV-infected children. STUDY DESIGN: A retrospective study including 56 children with chronic hepatitis B undergoing liver biopsy at median age of 8.1 years. In all patients demographic, anthropometric, clinical and laboratory data were evaluated at the time of liver biopsy. RESULTS: Steatosis was present in 2 (4%) children. BMI was significantly higher in 2 patients with steatosis compared with those without steatosis. Demographic, biochemical and virological parameters did not differ between children with and those without steatosis. CONCLUSIONS: Liver steatosis in HBV-infected children seems to be related to obesity and metabolic factors rather than to viral factors. Detection of steatosis in non-obese children with HBV infection requires a careful investigation to rule out other causes of fatty liver.
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