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  • Title: A new technique for inducing and releasing obstructive jaundice in rats.
    Author: Oruç MT, Ozmen MM, Han U.
    Journal: Eur Surg Res; 2009; 43(4):354-9. PubMed ID: 19828959.
    Abstract:
    AIM: It was the aim of this study to develop a simple, effective and reversible model of obstructive jaundice in rats. MATERIAL AND METHOD: Totally, 24 rats were divided into 3 groups: the sham group including sham-operated control rats who underwent laparotomy only (n = 8), the common bile duct standard ligation technique (CBD-SL) group including rats with CBD ligation using silk (n = 8), and the CBD new ligation technique (CBD-NL) group consisting of rats with CBD ligation by a new technique (n = 8). After release of the ligations, the CBD-SL group continued as the CBD-SL releasing group, and the CBD-NL group as the CBD-NL releasing group. RESULTS: It was observed that all the CBD ligated rats were both clinically and biochemically jaundiced but they were relieved after reversing the procedure. CONCLUSION: We present a simple, effective and reliable rat model which is suitable for studies which require a reversal of obstructive jaundice in rats.
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