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  • Title: Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis.
    Author: Teng D, Li C, Teng Y, Ouyang Y, Li Y, Teng W.
    Journal: Gynecol Obstet Invest; 2010; 69(1):24-9. PubMed ID: 19829002.
    Abstract:
    AIM: To clarify dynamic changes of IgG subtypes of thyroid peroxidase antibody (TPOAb) during the first postpartum year in Chinese patients diagnosed with postpartum thyroiditis (PPT). METHODS: We retrospectively collected serum samples before and 3, 6, 9 and 12 months postpartum from 58 PPT patients. Levels of TPOAb and its IgG subtypes were examined by ELISA. RESULTS: Titers of total TPOAb and its IgG subtypes were lowest before delivery in PPT patients. Following delivery, titers of total TPOAb increased. Concentrations of IgG1 and IgG4 subtypes increased for 3 months postpartum, then became stable. Concentrations of the IgG2 subtype increased gradually until 9 months postpartum. Concentrations of the IgG3 subtype reached a peak at 6 months postpartum and remained at a high level thereafter. In PPT patients with an episode of hypothyroidism, levels of total TPOAb and of the IgG subtypes as well as the IgG1/IgG4 ratios were significantly higher than those in patients with an episode of hyperthyroidism and normal controls. Correlations between titers of TPOAb and thyroid-stimulating hormone levels (positive) and free T(4) levels (negative) were seen 6 months postpartum. CONCLUSION: TPOAb is related to thyroid injury and the IgG1 subtype of TPOAb may play a major role in the damage of the thyroid in PPT.
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