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  • Title: [Flavonoids from Scutellaria baicalensis and their bioactivities].
    Author: Zhou XQ, Liang H, Lu XH, Cai SQ, Wang B, Zhao YY.
    Journal: Beijing Da Xue Xue Bao Yi Xue Ban; 2009 Oct 18; 41(5):578-84. PubMed ID: 19829679.
    Abstract:
    OBJECTIVE: To study the flavonoids of Scutellaria baicalensis and their bioactivities. METHODS: Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro. RESULTS: Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9). CONCLUSION: Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).
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