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  • Title: P-glycoprotein and drug resistance in acute leukemias and in the blastic crisis of chronic myeloid leukemia.
    Author: Carulli G, Petrini M, Marini A, Vaglini F, Caracciolo F, Grassi B.
    Journal: Haematologica; 1990; 75(6):516-21. PubMed ID: 1982999.
    Abstract:
    The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P-glycoprotein can be expressed constitutively in some cases; c) P-glycoprotein does not appear to be the only mechanism responsible for resistance towards anthracyclines and Etoposide.
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