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  • Title: Design, synthesis and biological activity of new strobilurin derivatives with a 1H-pyrazol-5-oxy side chain.
    Author: Li M, Liu CL, Yang JC, Li L, Li ZN, Zhang H, Li ZM.
    Journal: Nat Prod Commun; 2009 Sep; 4(9):1215-20. PubMed ID: 19831032.
    Abstract:
    A series of new strobilurin derivatives with a substituted pyrazole side chain (5 and 6) were designed and synthesized. The new derivatives were synthesized from substituted phenones as starting material via esterification, cyclization and condensation reactions. All compounds were identified by 1H NMR and IR spectral and elemental analyses. Preliminary biological evaluation showed that some of the compounds had good fungicidal activity against cucumber downy mildew (CDM) and wheat powdery mildew (WPM) at 6.25 and 1.56 mg L(-1), respectively. Some of the compounds showed insecticidal activity against armyworm (AW), green peach aphid (GPA) and culex mosquitoes at 600 mg L(-1).
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