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  • Title: The disposition of a histidine decarboxylase inhibitor (S)-alpha-fluoromethylhistidine in rats.
    Author: Sakurai E, Niwa H, Yamasaki S, Maeyama K, Watanabe T.
    Journal: J Pharm Pharmacol; 1990 Dec; 42(12):857-60. PubMed ID: 1983148.
    Abstract:
    An amino acid analyser method using ninhydrin was developed for (S)-alpha-fluoromethylhistidine (FMH) with a minimum quantitation limit of 0.2 microgram mL-1. The assay was used to study the kinetics of FMH in rat. After bolus intravenous administration of FMH hydrochloride hemihydrate (50 mg kg-1), plasma concentration decreased biexponentially with half-lives of 4.4 and 32.7 min. The distribution volumes of the central and peripheral compartments were 127.4 and 166.3 mL kg-1, respectively. The tissue concentration of FMH was highest in the kidney and also decreased biphasically. The FMH concentrations in other tissues were lower, but their tissue/plasma ratios of FMH increased continuously after FMH injection, indicating that FMH partitioned into these tissues and was lost from them very slowly.
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