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  • Title: 2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.
    Author: McGuigan C, Derudas M, Quintiliani M, Andrei G, Snoeck R, Henson G, Balzarini J.
    Journal: Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6264-7. PubMed ID: 19833513.
    Abstract:
    We report the preparation of 2'-alpha-F, 2'-beta-F and 2',2'-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2',2'-difluoro BCNA derivatives were markedly less (approximately 100-fold) antivirally active.
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