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  • Title: [Prevention of adhesions in abdominal surgery. A dose finding study with streptokinase/streptodornase].
    Author: Tuchmann A, Dinstl K, Depisch D, Wendt P, Blümel G.
    Journal: Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir; 1990; ():1041-5. PubMed ID: 1983482.
    Abstract:
    UNLABELLED: Measurement of intraperitoneal fibrinolytic activity on 50 patients having undergone abdominal surgery (four of them controls). Instillation of streptokinase/streptodornase (Varidase) into the abdominal cavity. Determination of total protein, plasminogen, antiplasmin, alpha 2 Mx-plasmin-complex, spontaneous fibrinolysis and fibrinolysis + activator at different points in time p.op. RESULTS: Intraperitoneal fibrinolysis may be stimulated by local substitution of a plasminogen activator (Varidase). Systemic effects are confined to a high dose. No impaired wound healing nor increased propensity to hemorrhaging occurred.
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