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  • Title: Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers.
    Author: Láng I, Nékám K, Deák G, Müzes G, Gonzales-Cabello R, Gergely P, Csomós G, Fehér J.
    Journal: Ital J Gastroenterol; 1990 Oct; 22(5):283-7. PubMed ID: 1983711.
    Abstract:
    The hepatoprotective and immunomodulatory effects of silymarin and amino-imidazol-carboxamid-phosphate were studied in 60 patients with compensated alcoholic cirrhosis of the liver in a one month double blind clinical trial. Treatment with both drugs normalized the elevated levels of aspartate aminotransferase, alanine aminotransferase and serum bilirubin, markedly reduced the high level of gamma-glutamyl transferase, increased lectin-induced lymphoblasttransformation, decreased the percentage of CD8+ cells and suppressed lymphocytotoxicity. None of these changes occurred in the placebo-treated group. Thus the hepato-protective effects of silymarin and amino-imidazol-carboxamid-phosphate are accompanied by changes in parameters of cellular immunoreactivity of the treated patients.
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