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  • Title: [Osteomalacia and renal tubular acidosis associated with analgesic abuse. A clinical case].
    Author: Valdivieso A, Flores F, Llach F, Felsenfeld AJ, Massardo L, Jacobelli S.
    Journal: Rev Med Chil; 1990 Jan; 118(1):58-66. PubMed ID: 1983808.
    Abstract:
    Osteomalacia is a multifactorial bone disorder. Main causes are vitamin D deficiency and phosphorus depletion. Among patients with renal insufficiency the incidence of osteomalacia is variable and probable related to impairment of the synthesis of 1,25 dihydroxy-vitamin D3 (calcitriol). We report a patients with severe osteomalacia, hyperkalemic tubular acidosis, low serum calcitriol levels and insufficiency associated to a prolonged overuse of analgesic drugs. Differential diagnosis and pathophysiology are discussed.
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