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  • Title: [Oxidative stress and trace elements affect the activity of sodium transporting systems in a cellular membrane of a erythrocyte].
    Author: Kedzierska K, Bober J, Kwiatkowska E, Stachowska E, Olszewska M, Chlubek D, Ciechanowski K.
    Journal: Ann Acad Med Stetin; 2008; 54(3):105-14. PubMed ID: 19839521.
    Abstract:
    We examined the activity of sodium transporting systems (STS) in a cellular membrane of erythrocytes in a group of 21 patients under chronic hemodialysis treatment with the dialyzing fluid containing glucose HD-g(+), and 22 patients dialysed with the fluid not containing glucose HD-g(-), 21 patients with chronic kidney failure already not treated with dialysis and 21 control group. We examined the concentration of antioxidative system cofactors, such as zinc, copper and selenium in erythrocytes and plasma. The marker of oxidative stress in erythrocytes and plasma was the concentration of TBARS. Among all STS we examined the activity of Na(+)/K(+) ATP-ase, Na(+)/K(+)/Cl(-); co-transport, Na(+)/Li(+) exchanger, Na(+), K(+)-outflow. Copper zinc and selenium as cofactors of antioxidative enzymes may reflect the antioxidative processes inside the organism undergoing the influence of free radicals.
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