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  • Title: Metastatic carcinoma of the neck of unknown primary origin: evolution and efficacy of the modern workup.
    Author: Waltonen JD, Ozer E, Hall NC, Schuller DE, Agrawal A.
    Journal: Arch Otolaryngol Head Neck Surg; 2009 Oct; 135(10):1024-9. PubMed ID: 19841343.
    Abstract:
    OBJECTIVE: To assess the efficacy of various diagnostic modalities in detecting occult primary tumor location. DESIGN: Retrospective medical record study. SETTING: Academic head and neck oncology practice. PATIENTS: A total of 183 consecutive patients with metastatic carcinoma of the neck from an unknown primary tumor during a 10-year period, after exclusion of those with previous history of head and neck cancer, a primary tumor site evident on physical examination, or primary tumors of the neck. MAIN OUTCOME MEASURES: Identification of primary tumor location by various imaging modalities and panendoscopy with directed biopsies. RESULTS: Primary tumor location was identified in 84 patients (45.9%). Preoperative imaging (computed tomography [CT], magnetic resonance imaging, positron emission tomography [PET], and/or PET-CT fusion scan) identified sites suggestive of primary tumor location in 69 patients. Subsequent directed biopsy of these sites yielded positive results in 42 cases (60.9%). The rate of successful identification of a primary tumor for each of the imaging modalities was as follows: CT scan of the neck, 14 of 146 patients (9.6%); magnetic resonance imaging of the neck, 0 of 13 patients (0%); whole-body PET scan, 6 of 41 patients (14.6%); and PET-CT fusion study, 23 of 52 patients (44.2%) (P = .001). The highest yield in identifying primary tumor sites was obtained in patients who had undergone PET-CT plus panendoscopy with directed biopsies with or without tonsillectomy: 31 of 52 patients (59.6%). CONCLUSION: Diagnostic workup including PET-CT, alongside panendoscopy with directed biopsies including bilateral tonsillectomy, offers the greatest likelihood of successfully identifying occult primary tumor location.
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