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  • Title: Chemical constituents of Crinum asiaticum L. var. sinicum Baker and their cytotoxic activities.
    Author: Sun Q, Shen YH, Tian JM, Tang J, Su J, Liu RH, Li HL, Xu XK, Zhang WD.
    Journal: Chem Biodivers; 2009 Oct; 6(10):1751-7. PubMed ID: 19842135.
    Abstract:
    A phytochemical investigation of the bulbs of Crinum asiaticum L. var. sinicum Baker resulted in the isolation of two new alkaloids, asiaticumines A and B (1 and 2, resp.), together with 21 known compounds, including nine alkaloids, four amides, five phenolic compounds, and three flavonoids. All 23 compounds were isolated for the first time from Crinum asiaticum L. var. sinicum Baker. Their structures were elucidated by spectroscopic methods. In addition, ten alkaloids, 1-10, were evaluated for their cytotoxic activities against human tumor cell lines A549, LOVO, HL-60, and 6T-CEM. Compounds 3, 4, and 7-10 selectively showed remarkable inhibition against one or more of the tested cell lines.
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