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  • Title: Steroidal sapogenins and glycosides from the rhizomes of Dioscorea bulbifera.
    Author: Liu H, Chou GX, Wu T, Guo YL, Wang SC, Wang CH, Wang ZT.
    Journal: J Nat Prod; 2009 Nov; 72(11):1964-8. PubMed ID: 19842682.
    Abstract:
    Four new steroidal sapogenins (1-4), named diosbulbisins A-D, two new spirostane glycosides, diosbulbisides A (5) and B (6), one new cholestane glycoside, diosbulbiside C (7), and the known compounds 8-10 were isolated from rhizomes of Dioscorea bulbifera. Their structures were elucidated by 1D and 2D NMR techniques, HRFTMS, and chemical methods. The unusual furospirostanol sapogenin skeletons, as found in compounds 3 and 4, are reported in the family Dioscoreaceae for the first time. Cytotoxicity of compounds 1-10 was evaluated using two human hepatocellular carcinoma cell lines (Bel-7402 and SMMC7721).
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