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  • Title: Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
    Author: Pato MT, Pigott TA, Hill JL, Grover GN, Bernstein S, Murphy DL.
    Journal: Am J Psychiatry; 1991 Jan; 148(1):127-9. PubMed ID: 1984696.
    Abstract:
    Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study. Both drugs led to statistically significant and similar improvements in scores on the Yale-Brown Obsessive-Compulsive Rating Scale and other obsessive-compulsive and depression scales. This preliminary result warrants further exploration with a larger sample and other serotonergic agents.
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