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  • Title: Regulated on activation, normal T cell expressed and secreted and tumor necrosis factor-alpha in septic neonates.
    Author: Shouman B, Badr R.
    Journal: J Perinatol; 2010 Mar; 30(3):192-6. PubMed ID: 19847187.
    Abstract:
    OBJECTIVE: Measuring serum tumour necrosis factor-alpha (TNF-alpha) and Regulated upon Activation Normal T cell Expressed and Secreated (RANTES) in neonatal sepsis and determining whether early and late onset sepsis were associated with differences in their concentrations. STUDY DESIGN: In 15 neonates showing clinical signs of early- or late-onset infection, serum TNF-alpha and RANTES were determined at first suspicion of sepsis and before starting antibiotics. Fifteen healthy neonates were included as controls. RESULTS: Serum TNF-alpha white blood cells and C-reactive protein (CRP) were significantly higher, whereas RANTES was significantly lower in the septic group compared with the non-septic group. There was no significant difference in RANTES or TNF-alpha levels between infants having early or late-onset sepsis. Similar to term neonates, premature neonates, responded to infection with increased TNF-alpha and decreased RANTES, with no statistical differences between both groups. CONCLUSION: In this study TNF-alpha is the best diagnostic test of neonatal sepsis, followed by CRP, when evaluated at first suspicion of sepsis.
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