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  • Title: [Changes of CD4+CD25+ regulatory T cells, IL-10 and TGF-beta1 levels in peripheral blood in children with asthma].
    Author: Li M, Song L, Zhang JB, Fang J, Li L.
    Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2009 Oct; 11(10):829-32. PubMed ID: 19849943.
    Abstract:
    OBJECTIVE: This study determined the changes of CD4+CD25+ regulatory T cells, IL-10 and TGF-beta1 levels in peripheral blood in children with asthma in order to explore immunologic mechanism of asthma attacks. METHODS: Seventy-four children with asthma attacks, twenty-eight children with stable asthma and twenty healthy children were enrolled. The percentage of CD4+CD25+ regulatory T cells in CD4+ T cells in peripheral blood was detected by flow cytometry. Serum levels of IL-10 and TGF-beta1 were measured using enzyme linked immunosorbent assay (ELISA). RESULTS: The percentage of CD4+CD25+ regulatory T cells and IL-10 levels in peripheral blood in the asthma attacks group were significantly lower than those in the stable asthma and the control groups (p<0.01) .The stable asthma group showed a similar percentage of CD4+CD25+ regulatory T cells and IL-10 levels to the control group. Compared with the stable asthma and the control groups, serum TGF-beta1 level in the asthma attacks group increased significantly (p<0.05). In the asthma attacks, the stable asthma, and the control groups, the percentage of CD4+CD25+ regulatory T cells in peripheral blood was not correlated to serum levels of IL-10 and TGF-beta1. CONCLUSIONS: The percentage of CD4+CD25+ regulatory T cells in peripheral blood and serum IL-10 levels decrease and serum TGF-beta1 levels increases in children with asthma attacks, which results in a decreased immunosuppressive effect. This might contribute to one of the immunologic mechanisms of asthma attacks.
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