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  • Title: Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation.
    Author: Han ZG, Miao CB, Shi F, Ma N, Zhang G, Tu SJ.
    Journal: J Comb Chem; 2010; 12(1):16-9. PubMed ID: 19852499.
    Abstract:
    A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH(4)OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.
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