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  • Title: Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
    Author: Shim J, Eid C, Lee J, Liu E, Chaudhary D, Boschelli DH.
    Journal: Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6575-7. PubMed ID: 19854645.
    Abstract:
    A series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles were prepared and evaluated as PKCtheta inhibitors. Optimization resulted in the identification of compound 15 with an IC(50) value 0.44 nM for the inhibition of PKCtheta with 150-fold selectivity over PKCdelta.
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