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  • Title: A novel assay for influenza virus quantification using surface plasmon resonance.
    Author: Nilsson CE, Abbas S, Bennemo M, Larsson A, Hämäläinen MD, Frostell-Karlsson A.
    Journal: Vaccine; 2010 Jan 08; 28(3):759-66. PubMed ID: 19857452.
    Abstract:
    Quantification of hemagglutinin (HA) by single-radial immuno diffusion (SRID) is the predominant method to ensure product potency in seasonal influenza vaccines. Here a new method for quantification of influenza virus using biosensor technology is presented. The method employs quantification of virus via an inhibition assay format using HA proteins for H1N1, H3N2 and B immobilized on a sensor chip. Initial results showed the assay to have higher sensitivity (detection range 0.5-10 microg/ml), higher precision and significantly lower analysis and hands on time compared with SRID.
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