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  • Title: Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays.
    Author: Wang ZQ, Saigusa S, Sasaki MS.
    Journal: Mutat Res; 1991 Jan; 246(1):179-86. PubMed ID: 1986262.
    Abstract:
    Human lymphocytes exposed to 0.02 Gy of X-rays in the G1 but not the G0 phase became less susceptible to the induction of chromosome aberrations of the chromosome type by subsequent exposure to 3 Gy of X-rays. The induction of chromatid-type aberrations was not affected by the pretreatment with the priming dose. The expression of this adaptive-type response was transitory, being maximum at 5 h, and disappeared at 9 h after the initial low-dose exposure. Cell-cycle analysis excluded the possibility of a spurious consequence of differential cell-cycle progression.
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