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  • Title: Swerilactones C and D, anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis.
    Author: Geng CA, Zhang XM, Shen Y, Zuo AX, Liu JF, Ma YB, Luo J, Zhou J, Jiang ZY, Chen JJ.
    Journal: Org Lett; 2009 Nov 05; 11(21):4838-41. PubMed ID: 19863146.
    Abstract:
    Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
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