These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Iontrophoretic application of autonomic mediators and cyclic nucleotides in the sinus node cells.
    Author: Tuganowski W, Kopeć P, Kopyta M, Weźowska J.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1977 Aug; 299(1):65-7. PubMed ID: 198678.
    Abstract:
    The effects of intracellular application of noradrenaline, acetylcholine, cAMP and cGMP were studied in the sinus-node of the rabbit. Noradrenaline and acetylcholine were without effect on electrical activity. In about one third of cases, cAMP increased, and cGMP decreased the slope of slow depolarization. These results suggest that adrenergic as well as cholinergic receptors which control the electrical activity of the sinus node cell are localized at the outer side of the cell membrane. It has also been shown that the cyclic nucleotides exert direct but opposite chronotropic effects.
    [Abstract] [Full Text] [Related] [New Search]